![]() ![]() We reviewed the gross specimen characteristics and read the immunohistochemical product instructions, the expiration dates of the antibodies, the localization of the positive antibodies, and the staining intensity interpretation criteria in detail. The HE-stained slides were reviewed by three pathologists to confirm the diagnosis. Twelve specimens were routinely fixed using 4% neutral formaldehyde, paraffin-embedded, and tissue-sectioned to a thickness of 4 μm, followed by HE staining and immunohistochemical analysis. Their clinical history, imaging data, and disease were analyzed and further confirmed via the relevant immunohistochemical analysis. ![]() Thirteen patients with prostate sclerosing adenopathy that visited the Second Affiliated Hospital of Kunming Medical University from January 2015 to November 2021 were enrolled and followed up. To further understand this condition, we aimed to investigate the histopathological morphology and immunohistochemical phenotype of this very rare prostate lesion and to further explore its associated biological significance and underlying mechanisms. In clinical treatment, surgical resection is still the best treatment option for sclerosing adenopathy of the prostate. Furthermore, since it is a rare lesion, to date, no large samples have been available for clinical pathology experiments. Compared with that prostate adenocarcinoma, sclerosing adenopathy has a lower incidence and a higher misdiagnosis rate. Moreover, the lesions are often positive for muscle-specific actin staining. However, sclerosing adenopathy tends to be a more focal lesion than sarcomatoid carcinoma, which is thought to arise from the myoepithelial cells surrounding the prostate, high molecular weight cytokeratins. The glandular components show nuclear atypia, including nuclear enlargement and prominent nucleoli. They are observed in 2% of the transurethral prostatectomy or prostatectomy specimens and are rare in small samples derived from prostate needle biopsy. These lesions are benign pseudotumor hyperplasia lesions that are very similar to those of small alveolar prostate adenocarcinoma and are often misdiagnosed as prostate cancer by primary pathologists due to their characteristic interstitial spindle cell proliferation and small glandular architecture. ![]() It can manifest as single or multiple lesions, in which good small glands and scattered single-cell components can be seen, forming the impression of cell-like features. Sclerosing adenopathy of the prostate is a rare pseudomalignant proliferative lesion with a distinct histomorphological and immunohistochemical phenotype that often resembles acinar adenocarcinoma but may also resemble sarcomatoid carcinoma. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |